Association of maternal thyroid peroxidase antibody during pregnancy with placental morphology and inflammatory and oxidative stress responses

Background Studies suggest that thyroid peroxidase antibody (TPOAb) positivity exposure during pregnancy may contribute to changes in placental morphology and pathophysiology. However, little is known about the association of maternal TPOAb with cytokines. This study focuses on effect repeated measurements Methods Based Ma’anshan Birth Cohort (MABC) China, levels were retrospectively detected first, second third trimesters. Placental tissues collected 30 minutes after childbirth, morphological indicators obtained by immediate measurement formula calculation, cytokine mRNA expression was real-time quantitative polymerase chain reaction (RT-qPCR) afterward. Generalized linear models mixed analyzed for relationships trimesters indicators. Results Totally 2274 maternal-fetal pairs included analysis morphology, 2122 Maternal early negatively associated length, thickness, volume, weight disc eccentricity, while positively correlated IL-6, TNF-α, CRP, CD68, MCP-1, IL-10, HO-1, HIF-1α GRP78. In mid-pregnancy, width area. late pregnancy, area, volume weight. Repeated measures showed tended increase CD68 MCP-1 decreasing area than negativity. GRP78, weight, eccentricity. Conclusion There be trimester-specific associations between inflammatory oxidative stress responses. The present throughout pregnancy. Early critical period